ACHE and Alzheimer disease: These include the selective acetylcholinesterase inhibitors donepezil and galantamine, the acetylcholinesterase and butyrylcholinesterase dual inhibitor rivastigmine (for early- to mid-stage AD) (2, 3), and the N-methyl-D-aspartate (NMDA) receptor antagonist memantine (for moderate or severe AD) (4).