Therefore, in this work we decided to evaluate changes in the expression of EMT cell markers characterized by the expression of epithelial (E-cadherin) and mesenchymal (vimentin, desmin and N-cadherin) markers; in human kidney tumor (786-O, ACHN and Caki-1) and non-tumor (HK-2) epithelial cell lines incubated with the CMs of hRAN and hRAT. Here, DES is linked to neoplasm.