Although Cai et al. reported that miR-542-3p was downregulated in glioblastoma cell lines, the expression level of miR-542-3p negatively correlated with the invasion of glioblastoma cells by targeting AKT145, and different expression levels of miR-542 were present between GBM BVZ subtypes, as shown in Fig. 2C. Likewise, Pang et al. found that downregulation of miR-590-3p in GBM tissues and cell lines resulted in increased migration and invasion by targeting ZEB1/2 (zinc finger E-box 1/2)46, but miR-590 expression was reversed between the BVZ subtype and the control of GBM in this study. Here, ZEB1 is linked to glioblastoma.