The mechanism of the recurrence of HCC after liver resection is not clear yet, it be related to tumor size, tumor number, AFP levels, tumor differentiation, microvascular invasion(MVI), cirrhosis, positive surgical margin and the metabolic syndrome and so on4,5, however, those indicators in daily clinical work is not convenient, and the predictive value of single index has certain limitation, such as AFP levels, poor sensitivity and the prediction is delayed6. This evidence concerns the gene AFP and Cirrhosis.