HSF2 and hepatocellular carcinoma: First, extracellular stress can upregulate DNAJC24 expression through transcriptional regulation of HSF2, and high expression of DNAJC24 can promote proliferation and motility of HCC cells, leading to poor prognosis of HCC patients; second, we confirmed that targeting DNAJC24 can affect the proliferation and autophagy of HCC cells by interfering with ammonia metabolism, thereby inhibiting the malignant development of HCC.