VIM and neoplasm: Importantly, as shown in the HCT116 CAM and B16F10 mouse tumor models presented in this section, as well as in the models described below, effective targeting of tumor vascular vimentin is independent of the intracellular expression level of vimentin in the tumor cells (Supplementary Fig. 2j) as vimentin is dominantly expressed in the vasculature in vivo and detected in the tumor secretome (Supplementary Fig. 5f, g).