The SL between ENDOD1 and TP53 was also recapitulated in coisogenic HCT116 cells (colon cancer): HCT116 cells expressing wildtype p53 remained viable, but those expressing an isoform of p53 (∆40p53)16 did not proliferate (Supplementary Fig. 4h). Here, ENDOD1 is linked to colonic neoplasm.