treatment when comparing TP53 WT and KO PDO5 (Fig. 5G) or CRC cell lines carrying WT or mutant TP53 (Fig. 5H) but the massive accumulation of apoptotic cells as determined by cCas3 and cPARP1 levels (Fig. 5G, S1H, and S1I). Here, TP53 is linked to colorectal carcinoma.