The 28up + 8down-feISC gene signature was present in Marisa (Fig. 5A), Jorissen, and TCGA CRC cohorts (Fig. S5B) associated with higher levels of the cell cycle regulator p21 (CDKN1A gene) (Fig. S5C), further suggesting a link between fetal traits and slow-cycling phenotype. The gene discussed is CDKN1A; the disease is colorectal carcinoma.