The separationwas driven primarily by CD9 (importance = 0.37), TENX (importance= 0.32), and di-N-acetylchitobiase (DIAC, importance = 0.28), withboth TENX and DIAC showing a downregulation with disease progressionand CD9 showing a stronger upregulation in early- than late-stagepancreatic cancer (Figure 6C and Supporting Information Figure 6B). Here, TNXB is linked to cancer.