In the early-stage pancreatic cancer, proteinsinvolved in the regulation of peptide secretion, cell communication,and chemokine production are overall downregulated including LEG10,which is essential for the suppressive function of CD25 positive regulatoryT-cells55,56 (Supporting Information Figure 6C), while proteins involved in the negative regulationof apoptotic process and receptor internalization (including proto-oncogenetyrosine-protein kinase Src (SRC) and CD9; Figure 6C and Supporting Information Figure 6C) are upregulated. This evidence concerns the gene SRC and familial pancreatic carcinoma.