Interestingly, in the present study, we found that, in addition to the impairment of glycemic parameters, serum lipid profiles, and liver enzymes in the PCOS group, IGF-1 was significantly increased, whereas this parameter was significantly decreased in the PCOS + MET group and PCOS groups treated with higher doses of RD extract, with improvement in glycemic and lipid parameters. This evidence concerns the gene IGF1 and polycystic ovary syndrome.