CYP17A1 and polycystic ovary syndrome: Elevated LH levels occur in PCOS due to disruption of the hypothalamic–pituitary axis, resulting in over-secretion of GnRH [7], which promotes the PI3K/Akt pathway, leading to overexpression of the ovarian CYP17A1 gene along with 17-α hydroxylase enzyme levels, increasing Progesterone to TT conversion [49].