HIF1A and acute respiratory distress syndrome: Finally, to further verify whether Dex could attenuate MIR-induced ALI by inhibiting HIF-1α, we injected LV-NC or LV-HIF-1α while administrating Dex, and we found that the Dex + LV-HIF-1α group exhibited upregulated HIF-1α expression in lung tissue (Figures 6A and B), alveolar and interstitial edema, hemorrhage, and inflammatory cell infiltration in lung sections, improved pathological score (Figures 6C and D), and increased W/D ratio (Figure 6E).