APEX1 and non-small cell lung carcinoma: To examine the speculation, we determined the expression of APE1 and IL‐6 and demonstrated the up‐regulated expression of APE1 (p < .001) in NSCLC tissues as well as the up‐regulated IL‐6 level (p < .001) in the serum of patients with NSCLC, relative to adjacent normal tissues (Figure 3H,I).