EZH2 and esophageal squamous cell carcinoma: Moreover, overexpression of full‐length EZH2 but not the truncated EZH2 (ΔSET) rendered ESCC cells resistant to CYH33, suggesting that the trimethylation of histone 3 at lysine 27 mediated by EZH2 and subsequent global transcriptional regulation is required for this process.