ADAM8 and esophageal squamous cell carcinoma: To confirm the resistance to CYH33 in ESCC mediated by EZH2, we generated KYSE510 cells stably expressing EZH2 by transfecting dCas‐VP64, MS2‐p65‐HSF1 and EZH2‐targeted sgRNA included in the CRISPR‐SAM library.