TARDBP and amyotrophic lateral sclerosis: A total of 10 patients with autopsy-confirmed SALS (mean [SD] age at death, 76.1 [8.5] years; 8 men [80%]) exhibited axonal phosphorylated TDP-43 (pTDP-43)–positive accumulations in intramuscular nerve bundles; the 12 control patients without ALS did not.