CYBB and neoplasm: Tumor-naïve Nox2−/− neutrophils produced ~ 12% less basal mitochondrial ROS than wildtype Nox2 neutrophils and, likewise, Nox2−/− TANs produce significantly less (23%; p < 0.0005) mitochondrial ROS than Nox2wt TANs (Supp Fig. 1B).