Luciferase-expressing mouse prostate cancer cells, RM1, which were derived from the mouse Ras-Myc oncogene prostate model [29], were injected intra-tibially in male Nox2wt and Nox2−/− mice (n = 9/group), which exhibit homozygous Nox2 expression. The gene discussed is CYBB; the disease is prostate cancer.