SOD2 and cancer: There was little change in the expression of neutrophil catalase and peroxidoxins (PRNXD1, 3, 5), enzymes involved in reduction of H2O2 to water [54]; however C42B significantly increased neutrophil SOD2, which is required for dismutase of superoxide to H2O2 [54, 55] and may contribute to cancer-induced neutrophil H2O2 accumulation and secretion.