CYBB and prostate cancer: Neutrophils generate reactive oxygen species (ROS), primarily to kill phagocytosed bacterial pathogens, via ATP-dependent NOX2 and mitochondrial (mtROS) oxidative phosphorylation [13, 25, 44]. We tested the impact of host Nox2 depletion on bone metastatic prostate cancer growth in vivo using an intratibial metastasis model of mouse RM1 prostate cancer cells.