(3) Exercise training suppresses early aged hypertensive heart-induced fibrosis pathways such as AT1R, FGF23, LOX-2, TGF-β, CTGF, p-Smad 2/3, MMP-2/TIMP-2, MMP-9/TIMP-1, uPA and collagen I. From the current study did support our expected hypothesis that exercise training might attenuate myocardial fibrotic pathways through decreasing AT1R and FGF23 in early aged hypertensive rats. The gene discussed is PLAU; the disease is benign neoplasm.