Serum and glucocorticoid-regulated kinase 1 (Sgk1), a multifunctional kinase that plays an important role in cellular stress response [8], is identified as a top-ranking gene target resulting from the elevated H3K4me3 in AD, and a short treatment with Sgk1 inhibitor also ameliorates synaptic and behavioral deficits in the P301 Tau AD model [7]. The gene discussed is MAPT; the disease is Alzheimer disease.