Connecting these observations to a likely role for LIGHT in driving lung tissue remodeling that is a feature of severe SSc and asthma and idiopathic pulmonary fibrosis (IPF), LIGHT-deficient mice, and mice therapeutically treated with LTβR-Fc, exhibited markedly less collagen deposition, bronchial smooth muscle mass, and airway hyperreactivity in T cell–dependent models of allergen-driven asthma and bleomycin-driven SSc/IPF (Doherty et al., 2011; Herro et al., 2015). Here, LTBR is linked to systemic sclerosis.