LTBR and colitis: In initial studies in models of colitis, T cell transfer into SCID mice or bone marrow chimeras with Tgε26 mice revealed that treatment with LTβR-Fc fusion protein, which neutralizes both LTαβ and LIGHT, reduced gut inflammation (Mackay et al., 1998), with subsequent experiments replicating those results in a model driven by a chemical hapten (An et al., 2005).