Increased levels of soluble LIGHT have been found in the circulation in atopic dermatitis or scleroderma, in part correlating with disease severity and several other biomarkers (Kotani et al., 2012; Gindzienska-Sieskiewicz et al., 2019), and increased levels in scleroderma skin lesions (Gindzienska-Sieskiewicz et al., 2019; Tsoi et al., 2019). This evidence concerns the gene TNFSF14 and scleroderma.