The aforementioned findings were directly linked with LIGHT when constitutively expressed LIGHT in T cells exhibited a number of features of Crohn’s disease–like pathology, including immune infiltration of the small intestine and colon, loss of goblet cells, crypt hyperplasia, villus atrophy, and IgA nephropathy (Shaikh et al., 2001; Wang et al., 2001; Wang and Fu, 2004). This evidence concerns the gene TNFSF14 and Crohn disease.