From a clinical standpoint, after initial demonstration of Graves’ immunoglobulins displacing IGF‐1 bound to GO orbital fibroblasts [45], subsequent studies have provided conflicting results, showing that a subset of patients with GO may have circulating IGF‐1R‐Ab with either inhibitory [46] or stimulatory IGF‐1R functional properties [47]. Here, IGF1R is linked to geroderma osteodysplastica.