In addition, STING−/− mice derived PMs also exhibited significant lower type I IFN response during S. Typhimurium infection at 2 h.p.i and 4 h.p.i (Fig. S3D), suggesting the cGAS-STING pathway was also involved in the initial activation of type I IFN response during infection (Fig. S3B). The gene discussed is STING1; the disease is infection.