Given the documented functions of DDX5 in oncogenic gene transcription,31, 33, 35, 37, 53, 83 various types of RNA splicing/regulation38, 39, 40, 41, 84, 85 and ribosome biogenesis,42, 43 as well as based on our breakthrough findings presented in this study, we provide an outline (Figure 10) to justify the high antitumour efficacy of FL118 acting as a potential molecular glue degrader through its distinct MOA plus other possible FL118 biochemical targets via ‘molecular glueing’ for future studies in the cancer community. The gene discussed is DDX5; the disease is cancer.