Strong positive immunostaining signals of HIF‐1α, as well as the gram‐stains in tumor sections could be observed (Figures S4 and S5, Supporting Information), suggesting the hypoxic microenvironment inside tumor tissue and the preferential colonization of BiL inside the tumor, probably due to the presence of the hypoxic, immunosuppressive characteristics with unique biochemical features in the tumor microenvironment.[31]. The gene discussed is HIF1A; the disease is neoplasm.