HK2 and cancer: Cancer stem cells (CSCs) have been defined as a small subset of cancer cells within the tumor bulk that exhibit self‐renewal and differentiation,[12] which contribute to tumor initiation, metastasis, relapse, and drug resistance.[13] Recently, liver CSCs have been identified by several stem cell markers, including ALDH1A1, CD13, CD133, CD24, EpCAM, and CD90.[14] Among the 67 oncogenic candidates, four metabolic enzymes (ACC1, ALDOA, FABP5, and HK2) were highly related to stem cell characteristics.