HK1 and hepatocellular carcinoma: HK inhibitors, such as 2‐deoxyglucose (2‐DG) and 3‐bromopyruvate (3‐BP), may be useful as therapeutic agents against HCC.[39] Our results demonstrated that 2‐DG could inhibit the tumorsphere formation, cell proliferation, and orthotopic tumor xenograft growth of HCC cells (Figure S8, Supporting Information).