HK inhibitors, such as 2‐deoxyglucose (2‐DG) and 3‐bromopyruvate (3‐BP), may be useful as therapeutic agents against HCC.[39] Our results demonstrated that 2‐DG could inhibit the tumorsphere formation, cell proliferation, and orthotopic tumor xenograft growth of HCC cells (Figure S8, Supporting Information). This evidence concerns the gene HK1 and neoplasm.