Some of the genes have been reported to be involved in the development and progression of HCC, including HK2,[25] fatty acid synthase (FASN),[26] fatty acid‐binding protein 5 (FABP5),[27] fructose‐bisphosphate aldolase A (ALDOA),[28] and acetyl‐CoA carboxylase 1 (ACC1, encoded by ACACA).[29] Moreover, some of the genes, such as guanylate kinase (GUK1), deoxyuridine 5'‐triphosphate nucleotidohydrolase (DUT), and carbonic anhydrase 5B (CA5B), were first reported to directly promote the tumorigenicity of HCC. Here, CA5B is linked to hepatocellular carcinoma.