GUK1 and hepatocellular carcinoma: Some of the genes have been reported to be involved in the development and progression of HCC, including HK2,[25] fatty acid synthase (FASN),[26] fatty acid‐binding protein 5 (FABP5),[27] fructose‐bisphosphate aldolase A (ALDOA),[28] and acetyl‐CoA carboxylase 1 (ACC1, encoded by ACACA).[29] Moreover, some of the genes, such as guanylate kinase (GUK1), deoxyuridine 5'‐triphosphate nucleotidohydrolase (DUT), and carbonic anhydrase 5B (CA5B), were first reported to directly promote the tumorigenicity of HCC.