CD4 and precursor B-cell acute lymphoblastic leukemia: In summary, on the basis of profiles (GSE48558 and GSE79533) and TARGET data matrix, a three‐gene risk score signature was constructed and the signature was an independent prognostic factor for CAYAs with B‐ALL; more importantly, immune cells infiltration containing T cells CD4 memory resting, monocytes, and eosinophils were highly abundant in high‐risk patients.