BCL2A1, gene encoding a member of the BCL‐2 family protein, it could mediate drug resistance such as asparaginase resistance in B‐ALL (Chien et al., 2015), cytarabine and doxorubicin resistance in AML (Simpson et al., 2006), fludarabine and ABT‐737 resistance in chronic lymphocytic leukemia (CLL) cells (Morales et al., 2005; Olsson et al., 2007; Ottina et al., 2012; Vogler et al., 2009). This evidence concerns the gene ASPG and B-cell chronic lymphocytic leukemia.