ATR and glioblastoma: At present, there are no active ATR inhibitor studies in GBM patients, although the PATRIOT (NCT02223923) trial is investigating the ATR inhibitor AZD6738 both as monotherapy and as part of combination therapy with palliative RT in the setting of solid tumors [65], and a Phase I dose escalation study of a new ATR-targeted agent elimusertib in combination with radiation in relapsed and newly diagnosed GBM is in advanced development.