PKM and cancer: Additionally, pathway analysis for potential direct targets revealed enrichments for metabolic adaptations in cancers (Figure 3B), diseases for which ZFP148 has known roles (16, 17), and included Psat1 and Psph, which may result in altered activity of enzymes (e.g., PKM2; Figure 3B and extended data in Dryad, ref. 46), which have roles in both cancer and insulin secretion (22, 50).