AR and pachyonychia congenita: Overall, our results show that across the PDX models we have studied, there are clear differences in the AR cistrome of the R and NR tumors, that the R-ARBS and N-RARBS are present in CRPC and not in benign prostate or primary PC, and that the R-ARBS are associated with developmental processes identified with specific AR binding in metastatic CRPC.