SCN1B and Sudden unexpected death in epilepsy: Further studies including using atrial-specific or SAN-specific Scn1b-null mice, which may have longer life spans and thus be suitable for more detailed physiological analyses, or knock-in mice expressing selected SCN1B DEE52 patient variants are necessary to explore whether targeting VGSC β1 regulation in the heart will open new therapeutic avenues to reduce SUDEP risk in patients with DEE52.