Interestingly, Chen et al. failed to detect common HCC mutations on 11 FNHs with genomic sequencing of TP53, CTNNB1, AXIN1, and APC which is not that astonishing considering the fact that—as exemplified by our case—the molecular mechanism of FNH hepatocarcinogenesis might be different from the mechanism/s observed in HCCs not associated with FNH40. This evidence concerns the gene APC and hepatocellular carcinoma.