For any individual patient however, information on the risk of metastatic development and uveal melanoma-related death will have to be adjusted upwards or downwards based on a range of other factors, including the size and location of his or her tumor, American Joint Committee on Cancer (AJCC) stage, BAP-1 expression, loss of heterozygosity of chromosome 3, presence of vasculogenic mimicry etc1,54–60. This evidence concerns the gene BAP1 and neoplasm.