Furthermore, naïve B cells co-expressing SLAMF1 and SLAMF3 and SM B cells co-expressing SLAMF1, SLAMF3, SLAMF5 and SLAMF6 were significantly increased in SLE, while cPC co-expressing SLAMF4 and SLAMF6 were reduced (Figure 4B). Here, SLAMF6 is linked to systemic lupus erythematosus.