Furthermore, naïve B cells co-expressing SLAMF1 and SLAMF3 and SM B cells co-expressing SLAMF1, SLAMF3, SLAMF5 and SLAMF6 were significantly increased in SLE, while cPC co-expressing SLAMF4 and SLAMF6 were reduced (Figure 4B). This evidence concerns the gene LY9 and systemic lupus erythematosus.