used a model mouse exhibiting global NLRP3 activation and several characteristics of the human disease (i.e., systemic inflammation and cartilage dysplasia) to show that activation of NLRP3 in myeloid cells, but not in mesenchymal cells, triggers chronic inflammation, which ultimately causes growth plate and epiphyseal dysplasia (44). This evidence concerns the gene NLRP3 and Epiphyseal dysplasia.