described a polymorphic autoinflammatory immunodeficiency with recurrent fever, dermatitis, IBD, PAP, and hypogammaglobulinemia caused by de novo heterozygous OAS1 gain-of-function mutations; they named the disease OAS1-associated polymorphic autoinflammatory immunodeficiency (OPAID) (13). The gene discussed is OAS1; the disease is pulmonary alveolar proteinosis.