PSMB8 and proteosome-associated autoinflammatory syndrome: Nakajo–Nishimura syndrome (NNS)/chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperature (CANDLE) syndrome/joint contractures, muscular atrophy, microcytic anemia, and panniculitis-induced lipodystrophy (JMP) syndrome is a form of proteasome-associated autoinflammatory syndrome (PRAAS1/MIM 256040) characterized by chronic inflammation and lipomuscular atrophy caused by homozygous loss-of-function mutations in PSMB8 gene encoding β5i, a component of the immunoproteasome (58, 59).