The subdominant A2/S269+ and A24/S448+ CD8+ TCRαβ repertoires were driven by restricted motifs, whereas the A1/ORF1a1637+CD8+, B7/N105+CD8+ and A24/S1208+CD8+ TCRαβ repertoires were more diverse across COVID-19 patients (111, 112, 116). This evidence concerns the gene CD8A and COVID-19.