IL6 and Hyperglycemia: In addition, chronic and transient hyperglycemia was also found to change the levels of miRNAs (miR-26a-5p, miR-26b-5p, let-7d-5p, let-7e-5p, miR-365a-3p, and miR-146a-5p) in adipocytes, which mostly converged to alter IL-6 transcription and can be instrumental in the development of inflammation and metabolic dysregulation of VAT (61).