Although, this correlation did not stem from an association between the two characteristics (R2 = 0.03; p = 0.265; Supplemental Figure 5D), the allele burden was significantly higher in CALR- compared to JAK2- mutated MPN (36% vs 10%; p = 0.016; Supplemental Figure 6E). The gene discussed is JAK2; the disease is myeloproliferative neoplasm.