PDCD1 and neoplasm: TIDE, a computational method developed by Peng Jiang et al. for pretreatment gene expression data, models two primary tumor immune-evasion mechanisms: the induction of T-cell dysfunction and the T-cell exclusion, which may contribute to its more precise prediction of patient response in the setting of first-line anti-PD-1 or anti-CTLA-4 treatment than PD-L1 level and TMB (57).