Immunoscore immunohistochemically quantifies the in situ immune infiltration based on the enumeration of two lymphocyte populations (CD3/CD45RO, CD3/CD8, or CD8/CD45RO) in CRC (68) and provides a score ranging from Immunoscore 0 (I0) to Immunoscore 4 (I4) according to calculated immune-infiltration density (69). This evidence concerns the gene CD8A and colorectal carcinoma.