Suppression of palmitoylation with 2-bromopalmitate (2-BP) and hydoxylamine eliminates the transcription of downstream inflammatory cytokine genes, thus the phenotype of STING-associated vasculopathy with onset in infancy (SAVI, an auto-inflammatory disease related to gain-of-function mutations of STING) could be improved. Here, STING1 is linked to STING-associated vasculopathy with onset in infancy.