Moreover, when compared with uninfected macrophages from healthy controls, the TB-infected AMs displayed an attenuated transcriptomic response and regulation of critical gene sets related to anti-TB responses including ISGs, IFITs, and GBPs (IFN pathway), AIM2 (inflammasome) FCGR1A (fc receptor pathway), and TREM (myeloid receptor pathway), which suggest modulation of macrophage-specific immune responses. The gene discussed is AIM2; the disease is tuberculosis.