Another study has reported circulatory macrophage (CD204+CD163+CD206+TLR4+CD80+CD86+) and monocyte (CD14+CD206+CD163+CD204+TLR4+CD80+CD86+) populations that expressed both M1/M2 markers in systemic sclerosis patients and in interstitial lung disease (ILD) (55). Here, TLR4 is linked to interstitial lung disease.