Comparing to HA-2-TCR-γδ T cells without the additional transfer of CD8, co-transferring of CD8 and HA-2-TCR to γδ T cells significantly increased IFN-γ and IL-4 production and exerted more efficient cytotoxicity against the HA-2-expressing CML and AML cells (142). Here, CD8A is linked to chronic myelogenous leukemia, BCR-ABL1 positive.