Except for the signal induced by TCRs, GD2-DAP10 CAR transferred γδ T cells used the solitary endodomain derived from the NKG2D adaptor DAP10 to mimic NKG2D co-stimulation, which induced significant cytokine production and equivalent killing as CD28-CD3ζ-CAR-γδ T cells against GD2+ Neuroblastoma and Ewing Sarcoma (140). The gene discussed is HCST; the disease is Ewing sarcoma.