Sera of healthy controls without RP, UCTD-risk-SSc, and non-fibrotic SSc patients were analyzed whereby elevated markers (CXCL10/IP-10, CXCL11/I-TAC, tumor necrosis factor receptor type II (TNFRII), and chitinase 3-like protein 1) were higher in UCTD-risk-SSc patients compared to controls (42). The gene discussed is TNFRSF1B; the disease is systemic sclerosis.