Authors sampled the serum of healthy controls without RP, UCTD-risk-SSc, lcSSc, and dcSSc patients for angiopoietin-2 (ang-2), CXCL16, e-selectin, sICAM-1, CXCL8, sVCAM-1, and VEGF. This evidence concerns the gene SELE and systemic sclerosis.