CCL2 and systemic sclerosis: Chemokines involved in extracellular matrix deposition, erroneous activation of fibroblasts, and anomalous immune system activation, including CCL2, MIP-1α/CCL3, CCL4, CCL7/MCP-3, and CXCL8, have been observed to be significantly upregulated in the serum of established SSc patients when compared to healthy controls (14–16).