In the SF of RA patients, the proportions of Treg cells and Th1-like Treg cells were significantly lower in the groups with elevated ESR (ESR >20 mm/h) or CRP (CRP ≥0.8 mg/dl) and in the groups positive for anti-CCP antibody (anti-CCP antibody ≥25 RU/ml). This evidence concerns the gene CRP and rheumatoid arthritis.