The occurrence and development of liver cancer is regulated by the immune system, and a lot of important immune molecules, CD44 (Yan et al., 2019; Dhar et al., 2018), IL-6 (Naugler et al., 2007; Wang et al., 2016), CLCX8 (Xiao et al., 2015; Yang et al., 2020). This evidence concerns the gene CD44 and liver cancer.