The median of Ki-67 was 40%, and it did not appear to be related to age or sex. The average tumor compartment volume was 40.8 cm3 for the contrast-enhancing zone, 62.7 cm3 for the edema zone, and 103.5 cm3 for total tumor volume. There was a significant association between Ki-67 index and edema zone volume (p=0.02), which was not the case for enhancing zone volume (p=0.10) and total tumor volume (p=0.33), (Figure 2). This evidence concerns the gene MKI67 and neoplasm.