To better understand the spreading pattern of 4R-tau pathology, we haverecently analysed the brains of N = 81 PSP-RS patients and proposed aneuropathological staging system with six sequential stages of PSP-RS, starting in thepallido-nigro-luysian system and spreading rostrally via striatum and amygdala to the cerebralcortex (frontal > temporo-parietal > occipital), and caudally to the medulla oblongata,pons and cerebellum.2 The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.