The order of regional atrophy revealed by the EBM (Fig. 1) broadly mirrors the sequential spread of tau pathology in PSP proposedby Kovacs et al.8 The earliest atrophy in our model occurs in the brainstem andsubcortical regions followed by progression caudally into the SCP and deep cerebellarnuclei and rostrally to the cortex. This evidence concerns the gene MAPT and supranuclear palsy, progressive, 1.