Indeed,a previous study in PSP showed that in vivo structural imaging reflectedthe independent contributions from tau burden and neurodegeneration at autopsy,19 while the link in Alzheimer’s diseaseis well established.20,21 However, the order in which brainregions show evidence of increased atrophy in vivo is currentlyunknown. The gene discussed is MAPT; the disease is supranuclear palsy, progressive, 1.