Currently, in breast cancer, especially in TNBC, multiple clinical trials of the application of combined immune checkpoint inhibitors with antiangiogenic drugs, such as multitarget receptor tyrosine kinase inhibitor anlotinib and small-molecule tyrosine kinase inhibitor apatinib (VEGFR2 inhibitor), which are manufactured in China, are being carried out (NCT03855358, NCT04914390, NCT04877821, NCT04405505, NCT04722718, NCT04303741, NCT03945604, and NCT03394287, et al.). The gene discussed is NTRK1; the disease is breast cancer.