A previous study demonstrated that the α3 (IV) chain encoded by COL4A3 could produce tumstatin, which can impede blood vessel formation in vivo and prevent tumor proliferation and metastasis (Hamano et al., 2003), and a significant association was observed between the abnormal expression of COL4A3 and tumor size, tumor grade, metastasis, invasion, and prognosis in several malignancies (Nie et al., 2013; Yang et al., 2021). This evidence concerns the gene COL4A3 and neoplasm.