A systematic analysis of protein half-lives in MCF-7 breast cancer cells found, in contrast, that CCT4 had the longest half-life (∼10.6 h), followed by CCT8, CCT7 and CCT2, with half-lives between 7–8 h, and CCT5 and CCT3 with the shortest half-lives of 4.6 and 2.5 h, respectively (Tong et al., 2020). This evidence concerns the gene CCT3 and breast cancer.