Profiling more than 9,000 tumors from the TCGA revealed that most cancers have genetic alterations in 10 major signaling pathways (cell cycle, p53, MYC, PI-3 kinase/AKT, JAK-STAT, Hippo, Wnt, and TGF-beta among others) (Sanchez-Vega et al., 2018). Here, TP53 is linked to cancer.