CCT itself could activate genes that drive cell cycling, since overexpression of CCT2 in luminal A breast cancer cells increased the gene expression of MYC and CCND1 that statistically correlated with CCT2 (Ghozlan et al., 2021), while depletion of CCT6A in an HCC cell line decreased levels of cyclin D (Huang et al., 2019). Here, CCT2 is linked to hepatocellular carcinoma.