Depletion of CCT1 in HCC cells produced a similar outcome with reduction of Wnt signaling molecules Wnt7b and β-catenin (Tang et al., 2020), while in colorectal cancers (CRC), the presence of circulating RNA for CCT3 (circCCT3) was linked to advanced CRC and stimulated vascular growth endothelial factor A (VEGFA) and the Wnt signaling pathway (WNT3). The gene discussed is CCT3; the disease is colorectal carcinoma.