Adenosine activates cAMP-elevating A2A receptors to inhibit CD8+, CD4+ lymphocytes, and natural killer (NK) cells but stimulates B and T regulatory lymphocytes (Treg), tumor-associated macrophages (TAMs), and myeloid-derived suppressor cells (MDSCs), thus establishing a typically immunosuppressive tumor microenvironment (TME) (Vijayan et al., 2017). Here, CD4 is linked to neoplasm.