By examining the secreted signaling, we found that the interaction between TB and uE was mediated by secreted proteins TGFA, NTF3/5, NRG1, MDK, INHBB, INHBABB, IL1A, IL10, HGF, FGF1/2/5/8/9/10, EGF and BDNF. Here, BDNF is linked to tuberculosis.