SETDB1 and cancer: A recent review has summarized many of the factors that can contribute to compensatory epigenetic repression of repeat regions in cancer cells, including histone methyltransferases such as Set Domain Bifurcated histone Lysine methyltransferase 1 (SETDB1), Enhancer of Zezte Homolog 2 (EZH2), and Euchromatic Histone Lysine N-methyltransferase 2 (EHMT2/G9a), histone demethylases (HDMs) such as Lysine Specific Demethylase 1 (LSD1) and Lysine Demethylase 5 (KDM5), as well as histone deacetylases (HDACs) (Chen et al., 2021).